There are different kinds of prayers. For instances 1 Timothy 2:1 highlights, "I exhort therefore, that, first of all, supplications, prayers, intercessions, and giving of thanks, be made for all men". Listed in this verse are different kinds of prayers you must know and pray. Moved by the Spirit, Apostle Paul in our theme scripture lets us know that with all kinds of prayers, we have to pray in the Spirit. He says, "Praying always with all prayer and supplication in the Spirit, and watching thereunto with all perseverance and supplication for all saints". This show that in whatever kind of prayer, you must prioritize praying in the spirit. Praying in the spirit here refers to praying in other tongues or strange tongues whose utterance is of the Spirit. This tells you the importance of praying in other tongues. This tells you that whether it is giving of thanks or intercessory prayer, there must be significant praying in tongues. In this way the prayer in your understanding (in the language you know) gets more perfectly aligned to God's will. You are able to get the right words of expression through your mind. In 1 Corinthians 14:15 the Spirit enlightens us through Paul, "What is it then? I will pray with the spirit, and I will pray with the understanding also: I will sing with the spirit, and I will sing with the understanding also". He emphasizes that praying with the spirit should have preeminence over your understanding. Praying in the Spirit and with the spirit (the human spirit) is one and the same thing, though "praying in the Spirit or Holy Ghost" broadly means praying the Holy Spirit inspired and guided prayer.